Hepatitis B Relaxed Circular DNA (PathogenAR)

The RC DNA was built with Molecular Maya's dsDNA Rigging Kit (https://clarafi.com/training/intro-mmaya-dsdna-kit/). Approximately 3200bp of DNA were created along a circular path, then bases were removed/added as necessary. RT from HIV (PDB 1T03) was used as a very general approximation of P Protein as a structure was not available.

An illustration of the life cycle from PathogenAR is included, with the step associated with this model highlighted.

This model was used in the PathogenAR Hepatitis B: The Hepatitis B Life Cycle Module in PathogenAR ( https://www.niaid.nih.gov/research/pathogenar-mobile-app )