Peanut allergen protein Ara h 2 bound by two neutralizing antibodies

Neutralizing antibodies targeting the peanut allergen Ara h 2 can effectively disrupt IgE-allergen interactions, preventing allergic reactions. These antibodies recognize specific epitopes on Ara h 2, creating potential use of these neutralizing antibodies to develop new treatments with oral immunotherapy for peanut allergies and other IgE-mediated food allergies.

Molecule Name: Ara h 2

Source: Peanut

Biological Role: Ara h 2 is a 2S albumin seed storage protein

Associated Allergies: Peanut allergy, IgE-mediated food allergies

Structural Notes: Epitopes identified that bind to the neutralizing antibodies consist of Ara h 2 residues #30-39 and #130-139.

References & Links: PDB 8DB4, https://www.jci.org/articles/view/164501

Model 1: Surface model of peanut Ara h 2 protein with binding epitopes highlighted

Model 2: Surface model of neutralizing antibodies with binding epitopes highlighted

Model 3: Peanut Ara h 2 protein with two neutralizing antibodies

Yellow - Ara h 2, Chain E

Green - 13T1 Antibody heavy chain, Chain A

Blue - 13T1 Antibody light chain, Chain B

Pink - 22S1 Antibody heavy chain, Chain C

Light Purple - 22S1 Antibody light chain, Chain D